Entner-Doudoroff Pathway
Entner-Doudoroff Pathway is an alternative pathway that catabolizes glucose to pyruvate using a set of enzymes different from those used in either glycolysis or the pentose phosphate pathway. This pathway, first reported by Michael doudoroff and Nathan Entner, occurs only in prokaryotes, mostly in gram-negative bacteria such as Pseudomonas aeruginosa, Azotobacter, Rhizobium.
In the pathway, glucose phosphate is oxidized to 2-keto-3-deoxy-6-phosphogluconic acid (KDPG) which is cleaved by 2-keto-3-deoxyglucose-phosphate aldolase to pyruvate and glyceraldehyde-3-phosphate. The latter is oxidized to pyruvate by glycolytic pathway where in two ATPs are produced by substrate-level phosphorylation.
This process yields one ATP as well as one NADH and one NADPH for every glucose molecule.
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